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Health Aspects
Websites describing ailments caused by fluoride

                                                                                                  This page is under development

Dr Hans Moolenburgh, who opposed the imposition of fluoridation in the Netherlands between 1952 and 1976, observed a variety of different ailments which were caused by fluoride. Back in the 1950s, 60s and 70s, each newly identified ailment caused by fluoride was a revelation and the case against fluoridation built slowly. With easy access to research articles and abstracts, most of which are translated into English even if authored in non-English-speaking countries, it is now far easier to establish a case against water fluoridation. 
(Go to for further information on the successful Dutch struggle against artificial fluoridation.)

There are no positive health benefits arising from the use of fluoride. It could be argued that there is a spin-off benefit in that delay in the growth of milk teeth in neglected fluoridated children postpones a modicum of dental decay until after the first dental examination at age 5.  There is also fluoridated toothpaste’s topical, bacteria-killing action. Finally, a fluoride compound was almost 100% effective in the first half of the 20th Century for dampening down the over-active thyroid gland (hyperthyroidism) when dermally absorbed.  This indeed was a benefit of absorbing fluoride - the only one identified to date!  However, had the treatment continued once the patient reached a normal thyroid state (euthyroid), then the patient would have flipped over into the hypothyroid state - two sides of the same coin.
(Go to )

There is a strong case to be made for asserting that some fluoride-induced illnesses are gender-related and/or that they occur at specific times in a person’s life. For example, thyroid specialists have observed that hypothyroidism (a condition which is exacerbated by fluoride and/or lack of iodine) occurs more often in older women.  Similarly, it is in fluoridated boys aged 6 - 8 years that osteosarcoma first develops and which is diagnosed a few years later. Because of different growth patterns and hormones, girls are not so likely to suffer from this often fatal bone cancer. (Bassin, E. et al. ‘Age-specific fluoride exposure in drinking water and osteosarcoma’.
(Go to Cancer Causes Control (2006) 17:421–428).

What other damages to health are caused by fluoride ingestion and absorption? The list is very long and it would not be advantageous for me to try to “re-invent the wheel”.  So this page briefly describes each health 'problem'  and then directs the visitor to the important website pages which give more authoritative detail.  A word of caution: many illnesses are caused by other factors so it’s important to keep an open mind.  For example, lead causes dental decay but most people only think of acidic and sugary foods and Streptococcus mutans as being the main culprits.  

(This list is being populated with health conditions caused by fluoride.  As an alternative, whilst it's being compiled, please go to which describes the various illnesses caused by fluoride. 

Alzheimer’s Disease

Keywords: alzheimer's fluoride aluminium

Aluminium, fluoride and its effect on the brain:  Click here to view web page

Bones - Reduced Cortical Bone Density and Exostoses

Keywords: cortical femur neck bone density appendicular skeleton trabecular bones fluoride collagen exostoses bone growths

Too much fluoride causes skeletal fluorosis,  This crippling condition is common in the naturally-fluoridated regions of India. The LINK takes you to a newspaper report of the treatment of this condition in Assam. Lesser amounts of fluoride bio-accumulated in the human body during a life-time exposure will alter the architecture of both appendicular bone (arms and legs, including the femur neck) and the trabecular (axial) backbone.   Whereas the latter bone becomes denser, the appendicular bones are rendered less dense due to the presence of fluoride.  It follows that populations exposed to 1ppm fluoride over a lifetime will exhibit varying degrees of reduction in the density of the long bones, wrist and ankle bones and, in particular, the femur neck.  This reduction in density reduces the strength of the bone.  What implications are there for those people who have a potential for osteoporosis?

How does this alteration of bone material happen?  Natural bone in humans and other animals is called hydroxyapatite.  It's chemical formula is Ca10(PO4)6(OH)2 ..  Note there is no 'F' present in this bone.  Fluoride is not necessary for the formation of healthy bones.  However, the chemical nature of hydroxyapatite makes it vulnerable to having some of the natural elements replaced by other elements.  Elements which substitute for the natural elements are carbonate, fluoride and chloride. 

“Bone strength depends not only on the quantity of bone tissue but also on the quality, which is characterized by the geometry and the shape of bones, the microarchitecture of the trabecular bones, the turnover, the mineral, and the collagen. … The determination of Bone Mineral Density (BMD) is not an accurate predictor of bone strength. The intrinsic properties of the matrix (mineral and collagen) also contribute to bone strength.

Collagen fibers provide the ductility and ability to absorb energy (i.e., the toughness). Alterations of collagen properties can therefore affect the mechanical properties of bone and increase fracture susceptibility."
Source: Viguet-Carrin, S., P. Garnero and P.D. Delmas (2006). ‘The role of collagen in bone strength’. Osteoporos Int (2006) 17: 319–336.

“In bones and teeth, fluoride becomes incorporated directly into the crystalline mineral phase, called hydroxyapatite, to form fluorapatite. The cancellous part of long bones and the surface of the shaft incorporate fluoride more rapidly than does the cortex. Developing bones and teeth take up more fluoride than do mature ones. In the absence of kidney impairment, adults therefore accumulate fluoride more slowly than children”.
Source: Waldbott, G.L. et al. (1978). Fluoridation: The Great Dilemma. Lawrence, Kansas: Coronado Press. ISBN 0-87291-097-0

“Fluoride exposure disrupts the synthesis of collagen and leads to the breakdown of collagen in bone, tendon, muscle, skin, cartilage, lungs, kidney and trachea.”
Source: and
Susheela, A.K. and Mohan Jha (1981), ‘Effects of Fluoride on Cortical and Cancellous Bone Composition’, IRCS Medical Sciences: Library Compendium, Vol. 9, No.11, pp. 1021-1022.

For a comprehensive bibliography on the topic, go to:

Exostoses are bone growths ... to be cont'd.

Dental fluorosis

Keywords: dental fluorosis fluoride
Go to Dental Fluorosis on this site.

NAFRINSE side effects
(No - it's not a joke!)

Physicians’ Desk Reference (US): “In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema, urticaria. Gastric distress, headaches and weakness have also been reported. These hypersensitive reactions usually disappear promptly after discontinuation of the fluoride.”

Enzyme inhibition

Keywords: Competitive inhibition Fluoride binding Mitochondrial membrane Noncompetitive inhibition succinic dehydrogenase

Succinic dehydrogenase is an enzyme complex whose action is a vital part of the Citric Cycle and the Electron Transfer Chain.  Both are essential processes in the mitochondria of each cell of the body.  On the mitochondrial membrane, in step 8 of the Citric Acid Cycle, Succinic dehydrogenase catalyses the oxidation of succinate to create fumarate.

Fluoride atoms (anions) in the blood stream are capable of crossing the outer cell wall and the mitochondrial membrane where it attaches itself to Succinic dehyrogenase, blocks the enzyme and prevents the enzyme reacting with succinate to create fumarate. The failure to create fumarate disrupts the production of ATP energy.

Fluoride does not kill cells, unlike cyanide which blocks the electron transfer chain that it closes down completely resulting in the death of the organism. However, Fluoride does reduce cell vitality and cells need to work harder to make the necessary amount of ATP energy.

Any substance which has a negative health effect on the internal workings of our cells is a poison. Since fluoride is not essential for the continuance of life, and our bodies are not constructed from this particular element, its presence in our bodies is totally undesirable. In most areas of England, natural calcium fluoride is found in very low concentrations (e.g. 0.04 ppm) so it does not cause a problem. Fluoride originating from industrial hexafluorosilicic acid does however cause a problem because of the unlimited amount of free Fluoride which is now available to us in tap water, convenience foods, swimming pool water, bathing water and toothpaste.

Fluoride also inhibits the enzyme in the thyroid gland which uses iodide to create a thyroid hormone. Where iodine is of too low a concentration and where fluoride is present, the organism becomes hypothyroid.

Fluoride inhibits the enzyme which assimilates protein found in the developing enamel in embryonic secondary teeth. If the protein is left in situ, it prevents enamel from becoming a dense matrix. This causes Dental Fluorosis.
Other undesirable enzyme inhibitions due to the presence of fluoride occur in the mammalian body and have been extensively demonstrated in laboratory experiment in vitro and in vivo.
Stachowska, E. et al.(2000). ‘Number of Fluoride ions binding to Succinate dehydrogenase during mixed inhibition’. Fluoride Vol. 33 No. 3 115-120 2000.  Click here to view article.


keywords: fibromyalgia  fluoridated medicines  fluoride poisoning

Jason Uttley, the author of The Cause of Fibromyalgia, has written a very fine internet article on why fibromyalgia and fluoride poisoning in the USA coincide with respect to the time frame of the practice of adding fluoride to water and to many drugs and the appearance of this previously unknown affliction.  He challenges readers suffering from fibromyalgia to remove fluoride from their environment (water, food, toothpaste, medicines, etc) in order to see if their symptoms start to disappear.


Keywords: hypothyroidism fluoride

This is a condition where the thyroid gland is underactive.  The condition where a person has an over-active thyroid gland is called hyperthyroidism.  We know that fluoride affects thyroid function because of successful treatments which were given to German patients in the period 1930-1960.  The treatment at that time was to give hyperthyroid patients hot baths in water containing a fluoride compound.  The majority of the patients became euthyroid (i.e. normal thyroid function) after a short time.  Partly because this treatment over a period of time was inconvenient for both patients and medical staff, hyperthyroidism is now treated using medicine. 

So, if fluoride can change a hyperthyroid state into an euthyroid state, what's to stop fluoride turning a euthyroid state into a hypothyroid state.  After all, all three states lie on the same continuum! The newsletter item which deals with fluoride baths and antagonism dates from 2000 and it's in its original state.  Nonetheless, the author, Andreas Schuld has been, and is, a very influential Canadian biochemist.

Hypothyroidism is also caused by a lack of iodine in the diet so people who are concerned that they may be developing this condition could try supplementing their diet with potassium iodide as well as taking avoiding action to prevent the ingestion and absorption of fluoride.  (You should always consult your doctor regarding the advisability of taking extra therapeutic supplements.)

Excessive hair loss, dry skin, increased sensitivity to cold, loss of appetite, extreme fatigue, depression, and a swelling in the front of the neck.

Fluoride Issues:
Thyroid UK:
Synthesis/Regeneration: A Magazine for Green Social Thought:


Two new studies have demonstrated that fluoride can impair male fertility. The first, in mice, found fluoride decreases sperm hyperactivation and Catsper1 gene expression. The second, in rats, reports that fluoride decreases sperm motility, enhances oxidative stress in testis, and increases testis apoptosis.

Spittle, B. (2009) Editorial: 'Halting the inertia of indifference: fluoride and fertility revisited'.  Fluoride 42(3)159–161 July-September 2009


“For me the most telling point in this debate is the level of fluoride in mothers' milk. At 0.008 ppm it is miniscule. If nature intended the new born baby to have fluoride this is where you would expect to find it. It is not there in any significant amount. This also means that a bottle-fed baby gets over 100 times the level that nature intended. We don't always know why nature is right but it usually is. She's been at it far longer than we have. I am particularly concerned about the impact of fluoride on the baby's developing brain and hormonal systems.”  (Dr Paul Connett, Founding Director, Fluoride Action Network)

Where silicofluorides are used, risk ratios for blood lead over the danger level of 10 micrograms/decilitre are up to 2½ times as high as where silicofluorides are not used.  This produces learning disabilities, ADD, hyperactivity, violent crime and more tooth decay. (NHANES III survey)

Irritable Bowel Syndrome (IBS)

Keywords: IBS Irritable Bowel syndrome fluoride

The orthodox medical fraternity doesn’t know what causes IBS …
… but we know that fluoride destroys the microvilli in the gut and that this disturbs the process of digestion causing pain, constipation, diarrhoea, bloating etc.

Self-cures involve avoiding fluoridated toothpaste, fluoridated water and all foods made in a fluoridated area, avoiding long hot baths in fluoridated water, and avoiding Indian and China tea which contain fluoride. I came across a network a little while back in which one of the networkers talked very knowledgeably about how cutting fluoride out of his diet had cured his IBS. A little time later, he moved to Essex where he became ill again. Enquiries led to someone telling him that parts of Essex have natural fluoride in the water supply. He switched to bottled water and his IBS cleared up. To read his account, go to the linked fileIf both people who posted to the lowcarber forum are reading this page, please get in touch with  The lowcarber forum can be accessed directly: .  Photographs of damaged microvilli can be viewed here: Fluoride-damaged microvilli

Physicians’ Desk Reference (US): “In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema, urticaria. Gastric distress, headaches and weakness have also been reported. These hypersensitive reactions usually disappear promptly after discontinuation of the fluoride.”

Kidney Disease

Keywords: Chronic Kidney Disease   Loops of Henle   Bio-accumulation 

“A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water." (Dr. Helmut Schiffl, 2008)

People have damaged kidneys for many reasons and not just because of their environment.  However, their overall condition is undoubtedly made worse if they ingest or absorb fluoride.  It is counter-intuitive to continue to use fluoridated tap water during kidney dialysis and yet this is what has been happening in the West Midlands.

A good introduction to the damage caused to the kidneys by fluoride

Home dialysis patients do NOT get extra pure water. Severn Trent guarantees continuity of supply but does not provide these customers with de-fluoridated water.  Customers with CKD (Chronic Kidney Disease) retain 70% of the fluoride in their bodies because the kidneys are less efficient than the kidneys of people who do not have kidney failure. In effect, this means that fluoride has a more damaging effect on teeth and bones when ingested by a patient with CKD because bio-accumulation is greater. The fluoride also accumulates in the kidneys, making them less efficient. And what happened to home dialysis patients during July and August 2008 when they received 2ppm F due to dosing plant 'breakdown' at Dimmingsdale WTW?


Keywords: osteofluorosis India

Severe cases of osteofluorosis are rarely seen in the developed world although minor signs are becoming increasingly common such as extoses and growth of fluoride-induced bone in the forearm. The problem is that the NHS is not geared up to distinguish osteoarthritis from osteofluorosis. So if you have arthritic fingers with swollen knuckles and you live in a fluoridated area, your GP can only tell you that you have osteoarthritis. Until the term osteofluorosis is taught in medical school and accorded an entry in UK medical books, any arthritis is treated as being the auto-immune disease that we are familiar with. The only way of testing for osteofluorosis is to check for fluoride levels in urine and blood. It ‘s also possible to diagnose osteofluorosis from a bone biopsy. How many GPs are going to ask for this to be done and how many patients know to ask for a biopsy to check for fluoride in arthritic fingers? So, until research is done and the results are accepted by the DH, your twinges and swollen fingers will be passed off as osteoarthritis.

Meanwhile, in India where the level of natural fluoride in the water is very high, crippling osteofluorosis is recognised as a real medical problem.  Indeed, in India, they are attempting to remove fluoride from the water.  The same is done in Essex in order to bring the natural fluoride level down to 1ppm. > osteoarthritis.html

Keywords: osteosarcoma fluoride

This is an often-fatal bone cancer. It’s induced by hexafluorosilicic acid and its attendant impurities, especially radioactive impurities and is more common in fluoridated young males than in fluoridated young females. The human male puts on a growth spurt between the ages of 6 and 8 at which time it is believed that fluoride and the radioactive impurities are laid down in the rapidly growing arm and leg 'long bones.
An introduction to the topic
Bassin, E. et al. ‘Age-specific fluoride exposure in drinking water and osteosarcoma’. Cancer Causes Control (2006) 17:421–428.

Sandhu, R., H. Lal, Z. S. Kundu & S. Kharb (2009) ‘Serum Fluoride and Sialic Acid Levels in Osteosarcoma’.
Biol Trace Elem Res DOI 10.1007/s12011-009-8382-1.


Skin Complaints

The following letters was uploaded to an on-line newspaper in August 2013.

Letter: Certain skin problems can be linked to fluoride

Before administering a medication to the public without informed choice, should not individuals have the right to know what the level of fluoride in their bodies is?  These analyses of fluoride in the blood and urine are available.

I have had analyses done of fluoride in the urine of several of my patients, including children, particularly those with certain skin eruptions. Some people, including children, have higher than average levels of fluoride in their urine. The skin eruption of certain of these patients with high fluoride has gradually cleared after stopping the fluoride toothpaste or fluoride mouth wash.

These skin eruptions have included urticaria, fixed drug eruption and rosacea. Concerned that the occasional child had a reported much higher level than normal of fluoride in the urine, I wrote July 6, 2006 to the Minister of Heath for Quebec reporting my observation.

Fluoride can also be measured in certain instances in the kidneys, liver and brain. (Disposition of Toxic Drugs and Chemicals in Man, 2011, Ninth Edition, Randell C. Baselt).

Dr. June Irwin

Hudson, Canada